I’ve been running a deck that uses both Data Ward and Macrophage paired with Sub Boost, and it’s been pretty solid. Obviously, yes, it’s no less vulnerable to ICE destruction, but the rest of the ICE suite is chosen to help shore it up against then decks that specialize in it. So far it really, really shits on Anarch, does quite well against Shaper, and is merely okay vs Criminal, depending on what their deck is doing. If they’re on a Power Tap deck, it’s pretty damn bad. If they’re not, it’s way better.
I think the main reason why Sub Boost works well in the deck is that the deck is fairly good already without it, but throwing a Sub Boost on one of those 2 ICE can sometimes just shut a server up completely. I only run 2 Boost (2 Data Ward, 3 Macrophage) so as to not over do it, and I rarely have it stuck in hand.
So far the fact that it adds Barrier to the Macrophages hasn’t mattered yet. It’s still a billion credits to get through.