I'm not sure the threat of immolate or copycat are so high as to WARRANT playing with single copies of ICE, but I think there is an increasingly large number of ICE that you might only WANT a single copy of. So the real question is, why do you take multiples of ICE, and what is the value doing/not doing so?
What are the benefits of 3 copies of ICE?
- Its the best ICE for the job, taking less than 3 doesn't make much sense.
- You want the consistency (especially early game) of certain pieces that are core elements of your strategy.
- It's a combo piece, 3 copies increases the chance you'll see it, and have it when you need it.
- Easier to pilot a deck 6 different ICE than a deck with 16.
Why would you run 1-2 copies instead?
- You don't want it too early, running fewer copies decreases the likelihood you will get it before you want it.
- You're happy to get it early, but it becomes a blank/cheap tax very quickly, you take one because its worth 1/16 to get it early, but you don't want to have to pitch 3 ICE that aren't doing anything for you if you draw it later.
- It has a corner case use. It's very helpful for certain matchups, but you've crunched the numbers and have decided to take a calculated risk against some more uncommon decks. You have the space for 1 card, that maybe you'll get against them and spare you that loss, but really, you can't afford the space/influence to justify 3.
- It's functions are not very multiplicative, and having more than 1 isn't really serving much of a purpose.
So yes, I think you could play a deck with 16 different ICE, I just don't think the benefits intrinsically outweigh the risks, and unless you're playing cards like Levy University, the variance is probably working against you more than the runner. Maybe with 3 Project Atlas and 3 Universities, it becomes much more stable to heavily run very specific ICE--but I wouldn't exclude 3 copies of the big hitters just to do it.