The Sprawl winds up being a natural fit if you like mission-based games. When I ran it, even though I was the only A:NR player in the group, we still wound up with an entertainment company, a biotech firm, a robotics/cybernetics company, and an infrastructure/financial/aerospace company, because they're just such iconic pieces of the cyberpunk setting. And 3 or 4 of the playbooks can start as competent hackers if you do want a cyberspace-focused game.
Just, as a word of advice, remind the players frequently how gear and intel work (maybe recommend a couple episodes of Leverage to get them into a flashback/retcon mindset), and be aggressive with the legwork clock. Otherwise they tend to get lost in the planning, especially if they're old-school RPers used to checking for traps on every door and such.