More seriously, I think losing siphon probably affects anarchs more. Criminals should still be able to find ways to win, and in Emergency Shutdown they still have one of the games most powerful events. Furthermore, with less RnD multiaccess, and without Jackson in the game, HQ pressure will likely become a much bigger deal and so their multiaccess will gain some value. Finally, they probably remain as good a faction at dealing with mass assets as Anarchs even without desperado (Anarchs lose whizzard at the same time).
Obviously this doesn't mean Criminal decks will be the same as they have been, but I would imagine they can still be good and am excited to see what they might look like. My first take would basically be a standard Andy deck with FIS, the ID swapped to Fisk, Doppelganger for desperado and equivocation for medium. Play a couple of Shutdowns instead of siphons and use mobius to keep hitting RnD, while also stuffing HQ for Legworks.
In the long run, I expect this to be good for Criminals. More than any other faction thier design space was tied up by the core set: they were never able to print anything remotely siphon like despite it being thier most iconic card and mechanic; they were trapped in tag-me for 2 whole cycles (arguably longer); none of thier non-run econ options were ever worth exploring. We might now see a larger number of balanced cards exploring these themes rather than just one or two overpowered ones.