LARLA seems required for me in case we go to the super late game and especially for Jinteki. Totally a personal preference, though. I'll try and track how many games in Seattle I actually use it.
The 2MU needs are directly a result of MO and Keyhole together (not to mentioned SMC). I'm struggling to see how you can afford the MU to have datasuckers, MO, and SMC all working together.
I do like Akamatsu for the cheap install and PS protection, but nothing worse than having to overwrite your MO.
Losing Desperado definitely hurts the economy where you can just run, run, run, and never click your Opus. The extra MU is nice with Grimoire, however, and the extra token on Parasite and Datasucker when you tutor can really give you some nice flexibility (not to mention Nerve Agent).