Outside of the cards/decks, there are a couple of themes that I think change the face of the game.
First for me, is that it’s really hard to lock R&D. You have to really invest into mostly shaper events to make this work. This helps out corp lategame, I believe.
Secondly, and conversely, is that most Jackson replacements just aren’t as good or as frequently available to clear out HQ, you see the buildup happening more extremely if you have corp backed in a corner. A strong remote saves lives! With Sansan gone I suspect dedicated FA might be harder as it depended on jackson fixing you the right agendas and recurring biotics.
Third: kill combo’s are really awkward. As a runner, you can let go of the idea that you need a similar amount of money to avoid imminent death. What you need is enough money to not be poor so that nonlethal traces don’t break your back. If you wanted another reason to play smoke: this is one.
Fourth: Despite the lack of direct threat accompanied with tags, tag-me is at the very least taking a break. Not just because of siphon, but while you’d love to play with counter surveillance (it’s an anarch r&d threat!), there’s no cards apart from god of war which do tags for benefit, and nobody gets excited about 0 strength, 2 to pump. So corp passive tagging becomes more potent in my eyes. Add to that that ice destruction is less frequent (it’s down to the events now and they mostly force you to face the ice anyway, so they are more costly, though I suspect still quite worth it), means ice like data raven is just that bit more annoying.