I'll be pretty disappointed if there are no more large box expansions, gotta say.
I get that Thrones had one per faction, but each faction also got their own box—netrunner factions have to share, so in that sense we've really only seen half a deluxe per faction. CoC got one per faction plus theme deluxes.
The really nice thing that deluxes give the designers (and players!) is the ability to really push a new line of play into a faction—theoretically, with enough support to make it competitive; or, like Order and Chaos, they can extend already existing themes (Viruses and Sabotage; Advanceable ICE) enough to (try to) keep them relevant.
I'm not sure it's worth thinking about rotation (since the announced rotation plan doesn't help anyone), but that's another topic.