In my experience, splashing a singleton Pol Op isn’t really going to matter much unless you have a build like Pitchfork where you can tutor it easily. I realize Pol Op isn’t included in the variant of the list I posted, but I know @spags had been playing a copy in a different version.
I played against him in a Chicago King of Servers event last year where I was playing Palana and I thought I had a bulletproof remote, only for him to run HQ, sacrifice a Fan Site and tutor Pol Op on the spot to bust my Caprice. To this day, that play was the most effective use of Political Operative I’ve seen.
The problem post MWL 1.2 is that any deck worth its salt playing defensive upgrades is going to have the ability to recur them with FiHP. Granted, there was a time when Palana/RP/EtF would use Interns, so perhaps it hasn’t changed much, but I think the general consensus is that FiHP is vastly superior. This means you can expect your singleton Plop to save you just once, which I’m not convinced will be enough.
Other posters in this thread have already identified that the other avenue that works great against defensive upgrades is to deny the corp economically with cards like Account Siphon, Vamp, etc. Obviously it’s going to come down to personal preference, but I would honestly err towards this route rather than packing my deck full of silver bullets which may or may not matter, the edge case being a deck that can actually tutor out the Pol Op with something like Artist Colony or even Hostage (click 1 HQ, 2/3 Hostage Plop, 4 run remote).