The most successful CD list I played was @dodgepong 's Credible Threat. At it's heart it was a deck that hinged on Mushin-no-Shin, and I think it did wonderfully there but that hinge can be a big turn off to a lot of players.
I also gave some extensive testing to @Marsellus 's Self-Destruct Chips / Batty list, and he moved it out of CD into EtF and now into Blue Sun Janus. Economy is a big deal with non-EtF decks it seems, and even his EtF list was scraping by economically.
The main problem statement is achieving three scenarios at once that make impactful use out of the brain damage:
1) Landing the brain damage in a functional suite.
2) Creating a board state where the Runner is pressured into getting brain or lose.
3) Utilizing the board state to actually force tough discards (which snowball into a score victory usually due to econ) or kills.
It's a tough thing to do but its doable, especially with a fat stack of cash. It's why I find CD decks particularly weak to Siphon spam. You aren't punishing Wyldside if they spend down to hand size with Faust making runs and accesses. I think Hopper Factory and Lateral Growth will expand the options for HB to explore non-BB Campaign economy suites.